Appendix A:
List of referral centres – Cellular Pathology Department SHYPS
| Address | Referral Repertoire | Reason for Selection | Accreditation |
| Cellular Pathology, Queen Elizabeth Hospital, Mindelsohn Way, Edgebaston, BIRMINGHAM B15 2WB |
CKIT, ROS1 and ALK FISH | This was the centre of the trials of these tests prior to approval by NICE
They have a long history, give good service & have good audit data |
UKAS: 8759 |
| Histopathology Dept Nottingham City Hospital Hucknall Road Nottingham NG5 1PB |
Referral of rare and difficult breast pathology cases | The regional centre | UKAS: 8162 |
| North East & Yorks Genomic Laboratory Hub Central Lab St James’s University Hospital Ashley Wing LEEDS LS9 7TF |
Soft tissue tumours | The regional centre | UKAS: 8096 |
| HMDS. Department of Pathology, Level 5 Bexley Wing St James Institute of Oncolocy Beckett Street LEEDS LS9 7TF |
Lymphoma diagnosis
Haematological diseases |
Specialist referral centre of Yorkshire | UKAS: 9305 |
| Genomic Health, 301 Penobscot Drive, Redwood City, CA 94063 USA |
For Oncotype DX | Trust has a contract with them | N/A |
| Leeds Molecular Mycobacteriology Unit, Department of Microbiology, The General Infirmary, LEEDS LS1 3EX |
PCR for TB | The regional centre | UKAS: 8157 |
| Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL |
Electron Microscopy and IHC staining and BRCA and HRD testing | Covers IHC stains which are not covered in our repertoire or other referral laboratories
Also, Oncologists choice for Hull patients |
|
| Mitochondrial Research Group, 4th Floor (The Medical School), University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH |
Mitochondrial diseases | NSCAG-funded reference centre for the diagnosis of mitochondrial diseases | UKAS: 9027 |
| Muscle Immunoanalysis Unit, Lower Ground Floor, Dental Hospital, Richardson Road, Newcastle upon Tyne NE2 4AZ |
Non-mitochondrial neuromuscular diseases | NSCAG-funded reference centre for the diagnosis of non-mitochondrial diseases | UKAS:9028 (Location code: B) |
| National Amyloidosis Centre, Royal Free Hospital, LONDON NW3 2PF |
Amyloid analysis | National centre for this work | Awaiting update. |
| National Centre for Mineral & Fibre Analysis, University of Wales Hospital, CARDIFF CF10 3NS |
Asbestos fibre analysis | National centre for this work | UKAS: 8987 |
| National Specialist Ophthalmic Pathology service, Department of Histology, E-Floor, Royal Hallamshire Hospital, Glossop Road, SHEFFIELD S10 2JF |
All ocular work excluding skin which are done in-house | NSCAG-funded reference centre for the diagnosis of ocular disease | UKAS: 8509 |
| Neuropathology, The National Hospital for Neurology and Neurosurgery, Queen’s Square, LONDON WC1N 3BG |
Referral of rare and difficult lesions | Runs the diagnostic EQA scheme. Have specialist pathologists
Referral service for Neuropathology |
UKAS: 8116 |
| Histopathology Department, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF |
Reporting of GIT specimens
EM samples |
Reciprocal agreement for reporting GIT specimens and SEYN Neuropathology | UKAS: 8509 |
| Source BioScience UK Ltd, 1 Orchard Place, Nottingham Business Park, NOTTINGHAM NG8 6PX |
Over capacity of histology specimen blocks and/or section | The only independent provider of this service to meet our requirements | UKAS: 9571 |
| Deptartment Of Musculoskeletal Pathology, Royal Orthopaedic Hospital Robert Aitken Institute of Clinical Research, University of Birmingham Vincent Drive, BIRMINGHAM B15 2TT |
Musculoskeletal second opinions | Specialist centre for Musculoskeletal pathology | UKAS: 9897 |
| Cellular Pathology, Barnsley Hospital NHS Trust, Gawber Road, BARNSLEY S75 2EP |
Immunocytochemistry slide exchange scheme | _ | UKAS: 8448 |
| Kath Lowe – Histology Manager Histopathology: Level A, Histology Laboratory, Rotherham General Hospital, The Rotherham NHS Foundation Trust, ROTHERHAM S60 2UD |
Immunocytochemistry slide exchange scheme | _ | UKAS: 9623 |
| LD Path, 3-4 The Courtyard, Vinnetrow Business Park, CHICHESTER PO20 1QH |
Over capacity of histology specimen blocks and/or section | _ | Awaiting update |
| Backlogs Limited, Silvaco Technology Centre, Compass Point, ST IVES PE27 5JL |
Over capacity of histology specimen blocks and/or section | _ | UKAS: 21408 |
| Health Services Laboratories (HSL), Advanced Diagnostics, Ground Floor, 60 Whitfield Street, LONDON WIT 4EU |
IHC, FISH and CISH staining | They have a larger repertoire of IHC stains and FISH/CISH probes which are not available in-house or through our other referral laboratories | UKAS: 9007 |
| Clinical Genomics, The Royal Marsden, NHS FT, 15 Cotswold Road, SUTTON SM2 5MG |
BRCA and HRD testing | Oncologists choice – Scunthorpe patients | UKAS: 20653 |
Appendix B:
List of locations and personnel for second opinions – Cellular Pathology Department SHYPS
| Address | Referral Repertoire | Reason for Selection | Accreditation |
| Prof C Fletcher Brigham & Womens Hospital, 75 Francis Street, Boston, Massachussetts MA 02115 (617) 732-8558 |
Second opinion | Expert in soft tissue work and urology and does not charge | Joint commission laboratory accreditation program (ID #5503) |
| Genomic Health, 301 Penobscot Drive, Redwood City, CA 94063 USA customerservice@genomichealth.com |
For Oncotype DX | Trust has a contract with them as they are the only ones whose test is NICE approved | CAP: 7186524 ISO 15189 3922.01 |
| Prof S Lucas / Dr E Calonje, Viapath Analytics Ltd, Guys & St Thomas Hospital, Westminster Bridge Road, LONDON SE1 7EG sebastian.lucas@gstt.nhs.uk |
Second opinion | Expert in Tropical Pathology | UKAS Accredited to ISO 18159:2012(ref number 9323) |
| Prof A Nicholson/ Dr A Rice, Royal Brompton, Sydney Street, LONDON SW3 6NP |
Second opinion | Expert in cardiothoracic pathology |
UKAS Accredited to ISO 18159:2012(ref number 8818) |
| Professor M Cook, Royal Surrey County Hospital, Egerton Road, GUILFORD GU27 7XX 01483 464065 |
Second opinion | National lead in skin pathology | UKAS Accredited to ISO 18159:2012 (ref number: 9727) |
| Dr B Mathew, Department of Histopathology and Molecular Pathology, Level 5, Bexley Wing, St Jame’s Institute of Oncology, Beckett Street, LEEDS LS9 7TF Bipin.Mathew@nhs.net |
Second opinion | Specialist dermatopathologist and expert in sarcoma cases | UKAS accredited to ISO 18159:2012 (ref number: 8924) |
| Professor E Rakha, Nottingham City Hospital, Hucknall Road, NOTTINGHAM NG5 1PB Emad.Rakha@nottingham.ac.uk |
Second opinion | National expert in Breast pathology | UKAS accredited to ISO 18159:2012 (ref number: 8162) |
| Professor Wolter Mooi, Department of Pathology, University Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam wj.mooi@vumc.nl |
Second opinion | Consultant choice | Accredited by ISO 15189 Awaiting update |
| Dr Awatif Al-Nafussi and Professor William Wallace, Department of Pathology, Royal Infirmary of Edinburgh, 51 Little France Crescent, EDINBURGH EH16 4SA a.alnafussi@ed.ac.uk |
Second opinion | Dr Al Nafussi is expert in soft tissue and gynaecological pathology. Dr Wallace is expert in Cardiothoracic pathology |
UKAS accredited to ISO 18159:2012 (ref number: 9546) |
| Dr J Wyatt, Department of Histopathology and Molecular Pathology, Level 5, Bexley Wing, St Jame’s Institute of Oncology, Beckett Street, LEEDS LS9 7TF judy.wyatt@nhs.net |
Second opinion | Expert in liver transplant pathology | UKAS accredited to ISO 18159:2012 (ref number: 8924) |
| Dr P Kitsanta, Training programme director in Yorkshire and Humber Royal Halamshire Hospital Glossop Road SHEFFIELD S10 2JF |
Second opinion | Consultant choice | UKAS accredited to ISO 18159:2012 (ref number: 8509) |
| Dr Candice Roufosse, North West London Pathology, Cellular Pathology, 3rd Floor Charing Cross Hospital (Lab Block), Fulham Palace Road LONDON W6 8RF |
Second opinion | The only centre for immunocytochemistry stain DNAJB9 on renal biopsies | UKAS accredited to ISO 15189:2012 (ref number: 9615) |
| Professor I Roberts Level 1, West Wing, John Radcliffe Hospital, Headley Way, Headington, OXFORD OX3 9DU |
Second opinion | Expert in renal pathology | UKAS accredited to ISO 15189:2012 (ref number: 9642) |
| Prof. Dr. Med. Abbas Agaimy, Leitender Oberarzt, Institute für Pathologie, Universitäsklinikum Erlangen, Krankenhausstrasse 8-10, 91054 Erlangen, GERMANY |
Second opinion | Expert in soft tissue, GI and Head and Neck pathology | Awaiting update |
| Department of Histopathology, Hammersmith Hospital, Imperial College Healthcare, De Cane Road LONDON W12 0HS |
Second opinion | Perform immunocytochemistry stains which are not in our repetoire | UKAS accredited to ISO 15189:2012 (ref number: 9615) |
| National Amyloidosis Centre, UCL Division of Medicine, Royal Free London NHS Foundation Trust, Rowland Hill Street, LONDON NW3 2PF |
Second opinion | National Centre where all cases of amyloidosis needs to be referred to. | UKAS accredited to ISO 15189:2012 (ref number: 9878) |
| Professor Jonathan Epstein, The John Hopkins Hospital, 1620 McElderry Street, Room 315, Reed Hall, Baltimore MD 21205, USA |
Second opinion | Specialist in prostate biopsies specifically and urology in general. | CAP accredited CAP number: 1353003 AUD-ID: 1008617 CLIA Number: 21D0709511 |