Every year, it is estimated that there are 13 million cases of typhoid and paratyphoid A fever combined, resulting in 133,000 deaths, mainly affecting school-aged children in Asia and Africa.

We are looking for healthy volunteers to take part in a study to test a new vaccine against typhoid and paratyphoid A fever.

In order to test if the vaccine works to protect against paratyphoid A fever, after vaccination with the new vaccine or a control vaccine, we will be challenging all participants with the bacteria that could cause paratyphoid fever. Participants will be treated with antibiotics as soon as they show symptoms of infection, or 14 days after drinking the bacteria even if they don’t have symptoms.

The study is being run by the Infection Research Group at Castle Hill Hospital, in collaboration with the Oxford Vaccine Group, and is funded by the Serum Institute of India.

If you are aged 18 to 55 years old, and in good health, you may be eligible to take part in the study. We will provide reimbursement for your time, inconvenience, and travel. Participants will receive up to £4585 if they remain in the study for the entire period and attend all the scheduled visits required for them. The total study participation time is 7 months, during this time you will be required to attend the Castle Hill Hospital Site for all study visits and the Oxford Vaccine Group or Liverpool School of Tropical Medicine on challenge administration day (travel will be arranged if applicable).

If you are interested in finding out more, please visit the website where you can access the Participant Information Sheet.

If you would like any further information regarding the study, email hyp-tr.infectionresearch.group@nhs.net or call 01482 461825 / 07823715171.